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CC chemokine receptor-2 (CCR2) play important roles in inflammation. The CCR2 V64I polymorphism already reported associated with many diseases; however, the association of CCR2 V64I polymorphism with tuberculosis is still unknown. Also, there is no report about the presentation of CCR2 V64I polymorphisms in Indonesian tuberculosis patients with rifampicin-mono resistant status have ever been published, for the best of our knowledge. This study evaluated the presentation of CCR2 V64I polymorphisms in Javanese rifampicin-mono resistant tuberculosis patients. In an ongoing molecular epidemiology study of human genomic polymorphisms and infection, 51 Javanese rifampicin-mono resistant tuberculosis patients in Dr. Moewardi General Hospital in Surakarta were enrolled in the study. The blood samples were aliquoted and fractionated. The nucleic acids were extracted from all blood samples, and subjected for the CCR2 V64I polymorphisms detection by a polymerase chain reaction-sequence-specific primers (PCR-SSPs) technique. PCR products were analyzed in 3% Agarose. CCR2 64V and 64I homozygote were found in 21.6% (11/51) and 23.5% (12/51) blood samples, respectively. The CCR2 VI genotype was found in 54.9% (28/51) blood samples. The CCR2 VI genotype was found predominant in Javanese rifampicin-mono resistant tuberculosis patients and may had association with the clinical progression.